শুক্রবার, ৩১ মে, ২০১৩

Iraqi officials say 16 dead in wave of bomb blasts

BAGHDAD (AP) ? A series of bomb explosions in Baghdad and the northern Iraqi city of Mosul on Thursday killed at least 16 people and wounded dozens in the latest eruption of violence rattling the country, officials said.

Iraq is facing its most relentless wave of bloodshed since the 2011 U.S. military withdrawal, deepening fears that the country is heading back toward the widespread sectarian fighting that pushed it to the brink of civil war in the years after the invasion.

More than 500 people have been killed in May. April was Iraq's deadliest month since June 2008, according to a United Nations tally that put last month's death toll at more than 700.

Most of Thursday's blasts went off in Baghdad. Car bombs killed four in the northeastern Shiite neighborhood of Binouq, and three died in a bombing at a market selling spare car parts in central Baghdad, according to police.

Police officials also said that a roadside bomb exploded on a police patrol in the largely Shiite central commercial district of Karradah, killing three people there.

The Karradah blast shattered glass and twisted metal signs on several storefronts, and left the stricken police unit's modified Ford pickup truck charred and mangled.

"What have these innocent people done to deserve this?" asked witness Sinan Ali. "So many people were hurt. Who is responsible?"

In the largely Sunni neighborhood of Azamiyah in the capital's north, a car bomb struck near a military convoy, killing three people, including two soldiers, according to police. Another 14 people were wounded in that attack.

Hospital officials confirmed the casualties.

In the northern city of Mosul, two police officers said a suicide bomber killed three when he blew himself up on a federal police checkpoint. Mosul is a former insurgent stronghold, located about 360 kilometers (225 miles) northwest of Baghdad.

All officials spoke on condition of anonymity because they weren't authorized to talk to the media.

There was no immediate claim of responsibility for the attacks but blame is likely to fall on al-Qaida's Iraq arm, which frequently carries out bombing attacks against civilians and security forces in an effort to undermine faith in the Shiite-led government.

Other militant groups have also grown more active in recent months, including the Army of the Men of the Naqshabandi Order, which has ties to members of Saddam Hussein's now-outlawed Baath party.

The attacks came hours after bomb blasts tore through two Baghdad neighborhoods Wednesday evening. At least 30 people were killed, including several members of a wedding party in the mixed Sunni-Shiite Jihad neighborhood.

The southwestern neighborhood was one of the earliest flashpoints in Baghdad's descent into sectarian bloodshed in the years following the 2003 U.S. led invasion. It housed mainly Sunni civil servants and security officials under Saddam Hussein's regime, though many Shiites now live there too.

Many of Jihad's Sunni residents earlier this year received threatening leaflets from a Shiite militant group, the Mukhtar Army, warning them to leave.

___

Associated Press writer Adam Schreck contributed to this story.

Source: http://news.yahoo.com/iraqi-officials-16-dead-wave-bomb-blasts-111342292.html

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বৃহস্পতিবার, ৩০ মে, ২০১৩

Lady Gaga Gets A Gun In First 'Machete Kills' Trailer

The preview shows of the 'Grindhouse' spin-off's many cameos, including Charlie Sheen and Mel Gibson.
By Kevin P. Sullivan

Source: http://www.mtv.com/news/articles/1708221/machete-kills-trailer-lady-gaga.jhtml

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Apple unveils new iPod Touch: 16GB storage, no back-facing camera, $229

Apple unveils new iPod Touch: 16GB storage, no back-facing camera, $229

Well, this is a little out of the blue. Apple has just outed a new iPod Touch that falls in behind its existing 2012 models. We're hesitant to call this the sixth generation, as it's more of a stripped down variant of what's already available. Not many of the specs have changed: the dimensions are identical, you're still getting a 4-inch Retina display, and the same dual-core A5 processor hums away inside. While the new model still has the front-facing FaceTime HD camera, it's lost the 5-megapixel main shooter, and a little bit of weight, to boot (0.06 ounces). Storage capacity has also taken a hit. The other iPod Touch comes in 32GB and 64GB varieties and a number of colors, but this new model sports just 16GB of storage and only comes in silver. Those lesser specs come at a lesser price, and you can snag one from Apple's online store now for $229, with retail locations getting it tomorrow. We reckon this won't be the only Apple product people'll be talking about today. Prepare for the cheaper iPhone rumor to make the rounds again.

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Via: The Verge

Source: Apple

Source: http://www.engadget.com/2013/05/30/apple-unveils-new-ipod-touch/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Clever Mug Catches Coffee Drips Before They Become Stains

Clever Mug Catches Coffee Drips Before They Become Stains

Harnessing the complex hydrodynamic properties of surface tension, this brilliantly re-engineered mug features a strategically engineered reservoir running around the circumference of the vessel's outer wall. Or, in other words, designer Kim Keun Ae added a groove that cleverly catches drips before they hit the table.

Cleaning the mug takes a little extra effort to get that groove sparkling, but otherwise it's a simple innovation that goes a long way to improving the coffee experience, particularly if you hate coasters. And while you can't buy one just yet, it won't be terribly difficult for someone to implement this simple improvement.

Clever Mug Catches Coffee Drips Before They Become Stains

[Yanko Design via Taxi]

Source: http://gizmodo.com/clever-mug-catches-coffee-drips-before-they-become-stai-510256316

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সোমবার, ২৭ মে, ২০১৩

Blackstone To Pull Money From SAC - Business Insider

REUTERS/Steve Marcus

Steven Cohen

May 25 (Reuters) - Billionaire hedge fund manager Steven A. Cohen is losing the financial support of Blackstone Group Inc , the largest outside investor in his embattled SAC Capital Advisors, which is yanking much of its client money, according to a letter reviewed by Reuters.

A pension consultant, in a May 21 letter to clients, said Blackstone has notified Cohen that it intends to "fully redeem" a significant portion of the roughly $550 million the investment firm has invested with the $15 billion hedge fund. The letter from pension consulting firm Russell Investments said Blackstone submitted its redemption notice to SAC Capital sometime before May 15 because of ongoing concerns about the insider trading investigation that continues to engulf Cohen's fund.

Blackstone's investment with SAC Capital is through several investment funds known as hedge fund of funds and also through separately managed accounts it maintains for clients. The decision to redeem from SAC Capital impacts only client money invested in its hedge fund of funds, according to the letter. It's not clear how much of the $550 million is in those hedge fund of funds and it is not clear what Blackstone is advising clients who have money in separately managed accounts that is invested with SAC Capital.

Russell did say in the address to its pension clients that Blackstone "expects to receive 100 percent of investors' capital by year-end." Russell, which manages $173 billion in assets and oversees a number of index funds, also provides advice to pensions and institutional investors on where to invest their dollars in hedge funds.

The timing of Blackstone's request to withdraw money from SAC Capital is critical because it came before the hedge fund told investors on May 17 that its cooperation with federal authorities was no longer unconditional. Soon after, news broke that federal prosecutors had issued grand jury subpoenas earlier this month to Cohen and several of his top executives, seeking their testimony about insider trading at the hedge fund.

The decision by Blackstone, which has invested with SAC Capital for at least a decade, is a big blow to the 56-year-old fund manager, who is widely regarded as one of the most successful traders of his generation. Blackstone - which manages about $46 billion in hedge fund investments for public pensions, foundations, corporations and wealthy individuals - is seen as something of a bellwether for other investors in the $2.2 trillion hedge fund industry because of its stature.

Representatives for Blackstone did not immediately respond when asked for comment on Saturday. An SAC Capital spokesman declined to comment.

The letter from Russell Investments, which was reviewed by Reuters, made no mention of the subpoenas on Cohen and his executives and was sent after a Russell representative talked to a Blackstone executive about the redemption decision. The letter said Blackstone decided to submit a redemption notice to SAC Capital after reviewing the terms of a $616 million deal SAC Capital reached in March with the U.S. Securities and Exchange Commission to settle allegations that the hedge fund's employees had engaged in insider trading in four stocks.

Blackstone, according to the letter, said the settlement with the SEC "did not give additional comfort that the issues at-hand were resolved."

A representative for Russell Investments did not respond to a request for comment about the letter from its Russell Research division.

Outside investors in SAC Capital like Blackstone, who account for roughly $6.75 billion of the $15 billion managed by Cohen, have until June 3 to decide whether to submit redemption notices for the second quarter. In the first quarter, outside investors notified Cohen they intend to withdraw about $1.7 billion of that $6.75 billion by year's end.

People close to SAC Capital said Cohen, who has roughly $8 billion of his money invested in SAC Capital, is bracing for another large round of redemption requests. The speculation is growing in the hedge fund world that if Cohen gets another large round of redemption requests, he may opt to return all the outside money and convert SAC Capital into a family office - an unregistered firm that manages money just for himself and his friends and family.

SAC Capital is one of the world's larger hedge funds with 1,000 employees.

Blackstone's hedge fund of funds invests client money with more than four dozen hedge funds, including SAC Capital, Pershing Square Capital Management, Elliott Management and DE Shaw & Co, according to people familiar with the private equity firm's asset management business.

The decision by Blackstone to redeem comes after the private equity and investment firm has stuck with Cohen throughout the course of the long-running investigation that has so far resulted in nine one-time employees of the firm being charged or implicated in insider trading schemes.

Cohen himself has not been charged with wrongdoing, but the investigation is seen as increasingly focusing on him and his firm.

In late April, lawyers for Cohen and his firm met with federal prosecutors in Manhattan to make their best case argument about why the hedge fund billionaire and his SAC Capital Advisors should not be charged with criminal wrongdoing. But people familiar with that meeting said the lengthy presentation did not impress federal prosecutors, who are now considering whether to use a racketeering law aimed at prosecuting the Mafia and drug gangs to pursue a criminal case against Cohen's hedge fund.

Source: http://www.businessinsider.com/blackstone-to-pull-money-from-sac-2013-5

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রবিবার, ২৬ মে, ২০১৩

Hipstamatic's photo filter app Oggl now open for everyone

Hipstamatic's photo filter app Oggl now open for everyone

Hipstamatic's subscription-based photo filter app is now publicly available on iTunes, a few weeks after its invite-only launch. Oggl is a free download, and you get five of its parent app's virtual lenses and films that you can mix and match to concoct your own filters from the get-go -- it also lets you edit a photo's effects after you've taken it. But if you find its small selection of lenses and films limiting and you'd prefer to have the whole enchilada (read: all Hipstamatic filters), you've got to part with $2.99 per quarter or $9.99 per year. No word yet on whether an Android version is in the works, but a preview of the app shown at the Nokia Lumia 925 launch event indicates that it's on its way to Windows Phone 8.

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Source: iTunes

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/9657yKz7Lug/

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iPhone biosensor cradle brings us one step closer to having tricorders (video)

iPhone biosensor cradle brings us one step closer to having tricorders video

It seems like every day we're getting a little bit closer to having tricorders, and today's no exception. Researchers at the University of Illinois at Urbana-Champaign have designed hardware and software that turns the iPhone into a powerful biosensor that's useful for toxin and pathogen testing as well as medical diagnosis. The package consists of a cradle that contains an assortment of lenses and filters which line up with the handset's camera, along with an app that guides the user through the testing process. At the core of the device is a photonic crystal slide which basically turns the iPhone into a high-resolution spectrometer. While the cradle only contains about $200 worth of parts, it's just as accurate as laboratory equipment costing tens of thousands of dollars, with the added bonus of being hand-held. The team just received an NSF grant to explore other applications for the device and is working on a cradle for Android phones. Hit the break for a demo video and a peek into the future.

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Source: University of Illinois

Source: http://www.engadget.com/2013/05/25/iphone-biosensor-cradle-brings-us-one-step-closer-to-having-tric/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/308394595?client_source=feed&format=rss

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Ally of Kosovo PM among five arrested for war crimes

PRISTINA (Reuters) - A close wartime ally of Kosovo's prime minister was among five people arrested by European Union police on Thursday on suspicion of war crimes during a 1998-99 insurgency against Serbian forces.

The EU police and justice mission in Kosovo, EULEX, did not release the names of those arrested, but a lawyer for Sami Lushtaku, mayor of the town of Skenderaj, said his client was among them and would appear in court on Friday.

Lushtaku has been regarded as close to Prime Minister Hashim Thaci since before the war, which saw NATO intervene with air strikes in 1999 to halt the killing and expulsion of ethnic Albanians by Serbian forces trying to crush an Albanian insurgency.

Lushtaku and Thaci were both senior commanders of the guerrilla Kosovo Liberation Army (KLA) from the hardline Drenica region. Lushtaku is now a member of Thaci's Democratic Party of Kosovo.

EULEX, in a statement, said the five had been investigated "for war crimes against the civilian population in the form of violation of bodily integrity and health of civilians held in a KLA detention center located in Likovc, Skenderaj municipality".

"One of the individuals is investigated also for war crimes in the form of killing of one civilian," it said.

The EU mission, established after Kosovo declared independence from Serbia in 2008, handles sensitive war crimes cases, in a country where the former guerrillas are revered as heroes and clan loyalties run deep.

(Reporting by Fatos Bytyci; Editing by Matt Robinson and Andrew Roche)

Source: http://news.yahoo.com/ally-kosovo-pm-among-five-arrested-war-crimes-140104361.html

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Arlington prepares for Memorial Day

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Katy Perry Gets Into Twitter Beef With Chief Keef!

Katy Perry Gets Into Twitter Beef With Chief Keef!

Chief Keef vs Katy PerrySinger Katy Perry took to Twitter earlier this week to say she was disgusted by the lyrics from rapper Chief Keef’s track “I Hate Being Sober”. Keef then took to Twitter to threaten the singer in a nasty tweet, ending with Perry apologizing for her previous comments. Katy Perry took to Twitter earlier this week ...

Katy Perry Gets Into Twitter Beef With Chief Keef! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/05/katy-perry-gets-into-twitter-beef-with-chief-keef/

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10 Things to Know for Friday

In this photo made May 12, 2013, Sergio Garcia, of Spain, left, shakes hands with Tiger Woods at the end of the third round of The Players championship golf tournament at TPC Sawgrass in Ponte Vedra Beach, Fla. Garcia apologized to Woods on Wednesday, May 22, 3013, for saying he would have "fried chicken" at dinner with his rival, a comment that Woods described as hurtful and inappropriate. (AP Photo/Gerald Herbert)

In this photo made May 12, 2013, Sergio Garcia, of Spain, left, shakes hands with Tiger Woods at the end of the third round of The Players championship golf tournament at TPC Sawgrass in Ponte Vedra Beach, Fla. Garcia apologized to Woods on Wednesday, May 22, 3013, for saying he would have "fried chicken" at dinner with his rival, a comment that Woods described as hurtful and inappropriate. (AP Photo/Gerald Herbert)

Boy Scouts from right, Joey Kalich, 10, Steven Grime, 7, and Jonathon Grime, 9, raise their hands at the close of a news conference held by people against the change in the Boy Scouts of America gay policy Wednesday, May 22, 2013, in Grapevine, Texas. Delegates to the Boys Scouts of America meeting nearby are expected to address a proposal to allow gay scouts into the organization. (AP Photo/LM Otero)

Lois Lerner, head of the IRS unit that decides whether to grant tax-exempt status to groups, listens on Capitol Hill in Washington, Wednesday, May 22, 2013, at the start of a House Oversight and Government Reform Committee hearing to investigate the extra scrutiny the IRS gave to Tea Party and other conservative groups that applied for tax-exempt status. Lerner later invoked her constitutional right to not answer questions and was dismissed by House Oversight Committee Chairman Darrell Issa, R-Calif. (AP Photo/J. Scott Applewhite)

This image made from video provided by Ayako Wada-Katsumata shows glucose-averse German cockroaches avoiding a dab of jelly, which contains glucose, and favoring the peanut butter. For 30 years, people have been getting rid of cockroaches by setting out sweet-tasting bait mixed with poison. But in the early 1990s, a formerly effective product stopped working. Some cockroaches had lost their sweet tooth, rejecting the corn syrup meant to attract them. Later studies showed they were specifically turned off by the sugar glucose in the syrup. Scientists reported Thursday, May 23, 2013 that the key is an altered behavior of certain nerves that signal the brain about foods. (AP Photo/Ayako Wada-Katsumata)

Your daily look at late-breaking news, upcoming events and the stories that will be talked about Friday:

1. HOW OBAMA IS DEFENDING DRONE STRIKES

The attacks are legal, effective and necessary as threats evolve, he says in a speech outlining America's post-war counterterror policies.

2. BOY SCOUTS END BAN ON GAY YOUTHS

The decision is unlikely to end a bitter debate over the Scouts' membership policies.

3. IRS OFFICIAL PLACED ON LEAVE

Lois Lerner is removed from her high-level post a day after she refused to answer lawmakers' questions about the IRS targeting tea party groups.

4. JODI ARIAS' FATE STILL UNDECIDED

The judge dismisses the jury after it fails to agree on a sentence for the convicted murderer. A new panel likely will be seated

5. LONDON SUSPECT KNOWN TO HARD-LINERS

The former head of a radical group says the man seen waving his bloodied hands on video is a Christian who converted to Islam around 2003.

6. WHERE TERROR BRIGADE MIGHT HAVE STRUCK AGAIN

The group that led the attack on a gas plant in Algeria claims responsibility for a new attack on a French-operated mine in Niger.

7. CHILDREN FACE THEIR OWN TORNADO CLEANUP

Students from a destroyed Oklahoma elementary school reunite with their teachers and collect whatever can be salvaged.

8. I'M NOT RACIST OR ANYTHING, BUT...

Can a person make a racist comment and not be a racist? Researchers find that many people ? of all backgrounds ? are unaware of their own biases.

9. WHO'S GOT A NEW IDEA TO COMBAT CHILDHOOD OBESITY

The prestigious Institute of Medicine says schools need to make sure kids get at least an hour of physical activity each day ? and PE should become a core subject.

10. COCKROACHES SAYING 'YUCK' INSTEAD OF 'YUM'

Evolving at warp speed, the bugs have learned to avoid sugar-flavored pesticides, researchers say.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-23-10-Things-to-Know-Friday/id-f484b950b50140abbbef0ce58b435f8b

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Sources: Florida man shot by FBI about to confess

The man shot dead by an FBI agent in Orlando, Florida early today was "about to sign a statement" admitting to a role, along with Boston Marathon bombing suspect Tamerlan Tsarnaev, in an unsolved triple murder in Massachusetts in 2011, two people with direct knowledge of the case told ABC News.

Ibragim Todashev "just went crazy," and pulled a knife during his interview with the FBI, said state and federal law enforcement officials briefed on the latest strange twist in the investigation of the Boston Marathon bombing.

One official said an FBI agent was stabbed several times, although his injuries were described by the FBI as "non-life threatening."

FBI agents and Massachusetts state police began to question Todashev after his name and phone number were recovered from the phone of the dead bombing suspect. Tamerlan Tsarnaev was killed in a shootout with police days after he and his younger brother Dzhokhar allegedly planted two bombs near the finish line at the Boston Marathon April 15, killing three and injuring more than 260 others. Dzhokhar was later captured and is in custody.

FULL COVERAGE: Boston Marathon Bombing

Todashev and Tamerlan Tsarnaev both fought mixed martial arts in the name of Boston's Wai Kru gym, where one of the 2011 triple murder victims, Brendan Mess, also trained, according to a former fighter there and law enforcement officials.

According to officials, Todashev was initially being questioned about any role in the marathon bombing when it emerged he had connections to the gruesome murder. There is no indication Todashev was tied to the bombing, sources familiar with the case said.

In the wake of the bombing, detectives developed DNA evidence linking both Tamerlan Tsarnaev and his younger brother Dzhokhar to the triple murder scene.

READ: 'Mounting Evidence' Boston Bombers Involved in 2011 Triple Murder

The three men who were killed had their throats slit and their bodies were left with cash and marijuana placed on top of them. The murder took place on September 11, 2011, the ten year anniversary of the al Qaeda terror attacks on New York and Washington.

Also killed with Mess were Raffael Teken and Eric Weissman. A spokesperson for the Middlesex County district attorney, which is handling the triple murder investigation, declined to make any official statement today.

According to a recent Florida police report, Todashev was arrested May 4 and booked with aggravated battery for allegedly fighting with a father and son over a parking space in a mall parking lot in Kissimmee, Fla. Todashev had told police he fought in self-defense as the son "came at him swinging" after Todashev pushed the father. The father did not want to press charges, but the son did, the report said.

In February 2010, Todashev had a run-in with the law in Boston when he was arrested after getting in a fight with strangers in which one witness said he was "clearly the aggressor," according to a police report.

Todashev was a lawful permanent resident holding a Russian passport, when he arrived in the U.S. in 2008 on a student visa, a senior U.S. official told ABC News.

Despite a recent assault arrest, his immigration file was devoid of derogatory information, the official said.

Freelance writer Michele McPhee is a Boston-based reporter and frequent contributor to ABC News.

CLICK HERE to return to The Investigative Unit homepage.

Also Read

Source: http://news.yahoo.com/fbi-shoots-florida-man-linked-160715309.html

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20 killed in 2 simultaneous car bombs in Niger

NIAMEY, Niger (AP) ? Niger's defense minister announced that 20 Nigerien soldiers were killed and another 16 injured when a suicide bomber detonated a car loaded with explosives inside a military installation in the city of Agadez on Thursday.

Minister of Defense Mahamadou Karidjo told reporters that a simultaneous explosion over a hundred miles away in the town of Arlit inside a uranium mine operated by French nuclear giant Areva injured 13. Five suicide bombers died in the twin explosions, he added.

The government of Niger has decreed a 72-hour national period of mourning. The attacks are believed to have been carried out by Islamic extremists based in neighboring Mali. If so, this would be the single-most damaging operation they have carried out since January when France launched a military intervention to oust them.

Source: http://news.yahoo.com/20-killed-2-simultaneous-car-bombs-niger-122347301.html

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বৃহস্পতিবার, ২৩ মে, ২০১৩

Hisense Sero 7 Pro Hands On: A Promising Nexus 7 Clone

Contrary to some rumors, Google didn't announce a refreshed Nexus 7 at I/O a little while back, but up-and-comers Hisense just announced a pretty good alternative to the aging tab. Its new Sero 7 Pro?the companies first foray into the tablet space?is basically a Nexus 7, but at only $150.

The Sero 7 Pro has all the Nexus 7-y features you want. A 1200 x 800 resolution screen, a Tegra 3 quad-core processor, 1GB RAM, and stock Android 4.2.2. All for $150. The compromise is that storage is capped at a meager 8GB, but to ease the blow, the Sero 7 Pro comes with an MicroSD expansion slot. And, it even has the Nexus 7 beat by including a 5MP rear-facing camera, and HDMI output. HP's Slate 7 has been pushing in on the Nexus 7 a bit too, but it's a shade more expensive at $170, and doesn't pack in some of the perks that the Sero 7 Pro has.

We got a little hands on time and the Sero 7 Pro doesn't feel like a cheap tablet. It's got a solid build, remeniscient of the Nexus 7 it's trying so hard to app. The back is hard, textured plastic that feels less than premium, but not all out bad. The performance is smooth, thanks to Nvidia's Tegra 3, and running stock on pretty much the exact specs of a Nexus 7 delivers a pretty comparable experience. The OS does come UI-skinned, with a few pack-in apps (like Walmart) but those are all easily removed. It's better than you'd expect for a $150 tablet.

We're due for a Nexus 7 refresh here sometime soon, and chances are it'll be a pretty nice overhaul of the existing model, but things like a MicroSD slot are very very unlikely to ever show up in a Nexus device. HiSense may not be the biggest name, but it's first tablet offering seems pretty damn good for the low end of the spectrum. It's rolling out to a Walmart (ugh) near you tomorrow.

Source: http://gizmodo.com/hisense-sero-7-pro-hands-on-a-fantastic-nexus-7-clone-509516366

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PTC angry after Ke$ha drinks pee on TV

TV

49 minutes ago

On Tuesday night's episode of "Ke$ha: My Crazy Beautiful Life," the "Die Young" singer knocked back a bottle of her own urine, and that act put the chart-topper at the top of the Parents Television Council's list of TV trouble.

In fact, the PTC believes MTV's decision to air Ke$ha's outrageous behavior perfectly illustrates why cable networks shouldn't be bundled together in one package. Just before the episode aired, the organization issued a press release, calling on Congress to get involved.

?If given the opportunity, I can?t imagine that parents would want to pay for a cable network that airs an episode of a pop star drinking her own urine," the message, penned by PTC president Tim Winter, read. "And that is why Congress needs to take seriously the idea of giving consumers the ability to choose and pay for only the cable networks they want."

After warning parents and grandparents to "take appropriate measures" where the Ke$ha docuseries is concerned, Winter added, ?Before critics say that parents can just ?change the channel,? they miss the larger point. It is an outrage that this kind of disgusting, vile content is being subsidized by each and every cable subscriber."

As for Ke$ha, she ignored the PTC flap. After the episode aired, she just played the controversy for laughs with her over-3 million followers.

Long before the urine-drinking stunt aired, Ke$ha spoke to The Hollywood Reporter about it, telling the publication she "wouldn?t recommend it," and not surprisingly, she found it "pretty gross."

(Warning for those with weak stomachs: Ke$ha doesn't drink up in the following clip, but she does discuss her beverage of choice and shows off a fresh sample -- very fresh.)

MTV has not yet responded to a request for comment.

Of course, Ke$ha's on-air act is only the latest boob-tube antic to get the attention of the watchdog group. Over the course of the past year or so, the PTC has also urged sponsors to abandon "America's Got Talent" after the reality competition dared to hire Howard Stern and even slammed "The Walking Dead" for its "brutally intense gore."

Source: http://www.today.com/entertainment/ptc-calls-congress-get-involved-after-ke-ha-drinks-urine-6C10021069

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Who's to blame for murky regulation in IRS scandal: Agency or lawmakers?

The IRS should move unilaterally to fix the law sitting at the root of the agency?s targeting of conservative groups, according to Senate Democrats who grilled the agency?s two most recent chiefs at a Senate Finance Committee hearing on Tuesday.

Plenty of questions remain unanswered after senators lit into the two men, Steven Miller and Doug Shulman, about the agency?s managerial competence, the thoroughness of its investigation into the matter given that the IRS has yet to identify exactly who is responsible for the targeting, and whether IRS officials were less than forthcoming with members of Congress during 2011 and 2012 when lawmakers were looking into allegations that eventually proved true.

But they were nearly as irate that the IRS claimed it was overwhelmed and confused about how to evaluate applications for tax-exempt status but did nothing to clarify the regulation at the crux of its discomfort.

RECOMMENDED: Playing the IRS card: Six presidents who used the IRS to bash political foes

?Why didn?t you do anything on your watch to correct it?? asked Sen. Ron Wyden (D) of Oregon. ?When the lines are blurring on this disclosure issue, as far as I can tell, you all didn?t do anything to correct the problem in a meaningful way. And I find that very regrettable.?

There?s been no legislative fix proffered for what actually occurred ? no lawmakers or IRS officials were making excuses for the agency?s decision to give extra scrutiny to scores of conservative groups? applications for 501(c)(4) tax exempt status.

That tax status, which is offered to so-called social welfare organizations, is sought by many groups on both sides of the political spectrum because it allows organizations to engage in some political activity while not disclosing their donors.

The problem for the IRS arises in attempting to determine whether an organization is primarily involved in political activity or not. The original law as passed by Congress, as several Democratic senators noted on Tuesday, says 501(c)(4) organizations must be ?exclusively? devoted to charitable, educational or recreational purposes.

When the IRS began implementing that rule half a century ago, however, they decided that exclusively really meant not ?primarily? engaged in political activity, leaving the door open for groups like the Sierra Club or the AARP to claim the status but devote less than half their activities to politics.

But figuring out just what counts as political activity and what?s an educational offering tied to social welfare is often in the eye of the regulator rather than a definitive science.

Because the IRS, along with the Treasury Department, handles the regulations that spring from the tax code, ?the IRS should be able to fix it on their own,? says Annette Nellen, a professor of accounting at San Jose State University. ?The language in the statute does say ?exclusively.? ?

Members of Congress look at the original law and say, like Sen. Ben Cardin (D) of Maryland, ?I don?t know what else we can do.?

?When you say ?exclusively? ? What stronger word do you want us to use?? Senator Cardin says.

Citizens for Responsibility and Ethics in Washington (CREW), a government watchdog group, is even suing the IRS, asking a court to require the organization to reconcile the differences between what the law says and what the IRS does.

Why didn?t the agency take on the issue previously? IRS officials argued that the agency was caught flat-footed with a wave of applications for 501(c)(4) status, which doubled between 2011 and 2012 in the aftermath of the Citizens United Supreme Court decision that allowed corporations and labor unions to participate more aggressively in the political process.

And the bureaucracy is notoriously hesitant to take on such large political issues on its own, says Melanie Sloan, CREW?s executive director.

?They?re afraid to take a position,? Ms. Sloan says. ?All that happens is they get beat up no matter what they do.?

Case in point: In 2010, Democrats led by Sen. Max Baucus of Montana asked the IRS to look into such groups because of concerns groups fully committed to politics were hiding behind the social welfare exemption to shield their donors from public scrutiny.

The problem? The IRS wasn't doing enough, allowing too many groups to get the status.

But Republicans lead by Sen. Orrin Hatch (R) of Utah rapped the IRS in 2011 when the IRS sent letters to donors to 501(c)(4) groups reminding them that gifts to those groups over $13,000 are subject to the federal gift tax. Senator Hatch argued that those letters were designed to intimidate conservative donors.

The problem? After 30 years of failing to enforce the gift tax law, the IRS was suddenly doing too much.

Mr. Shulman said that the IRS did not act because Congress has asked the service to do too much with too little funding.

?Treasury ought to look at the regulations, and all I can say is that this is a very hard task given to the IRS,? said Shulman, who left the agency after his term expired in November of 2012.

Given all the agency?s other responsibilities, ?to also have this piece of the operation that by the law has to be asking questions about political activities is very difficult,? Shulman said.

Moreover, Shulman turned the question back around on Congress: If this was such a big problem, he wondered, why had Congress done nothing to address it for half a century?

?This was a regulation, a Treasury regulation, that?s been in effect for many years,? Shulman said. ?This is a place that Congress should look. Because where I sit the IRS is given a very, very, very difficult task,... You can do some political activity, but you can?t do too much.?

San Jose State?s Professor Nellen points out that congressional inaction on the regulation over such a long time is tantamount to Congress indirectly endorsing the IRS?s interpretation.

?Congress knew they were interpreting these rules in a certain way,? she says.

Senator Hatch agreed that the onus falls on Capitol Hill.

?It?s Congress?s obligation? to fix the statute, said Hatch, the committee?s ranking Republican, ?we ought to do it the right way.?

Tax reformers like Senator Baucus and House Ways and Means Chairman Dave Camp (R) of Michigan have vowed to include a rewrite of these laws in their push for comprehensive tax reform.

But can Congress muster the will to confront an issue that?s been lingering for years?

?Congress doesn?t seem to be in any rush to tell them what to do,? says Sloan. ?Congress hasn?t been in a rush in the last 50 years to tell them what to do.?

RECOMMENDED: Playing the IRS card: Six presidents who used the IRS to bash political foes

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Source: http://news.yahoo.com/whos-blame-murky-regulation-irs-scandal-agency-lawmakers-001350809.html

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Practice makes perfect? Not so much

Tuesday, May 21, 2013

Turns out, that old "practice makes perfect" adage may be overblown.

New research led by Michigan State University's Zach Hambrick finds that a copious amount of practice is not enough to explain why people differ in level of skill in two widely studied activities, chess and music.

In other words, it takes more than hard work to become an expert. Hambrick, writing in the research journal Intelligence, said natural talent and other factors likely play a role in mastering a complicated activity.

"Practice is indeed important to reach an elite level of performance, but this paper makes an overwhelming case that it isn't enough," said Hambrick, associate professor of psychology.

The debate over why and how people become experts has existed for more than a century. Many theorists argue that thousands of hours of focused, deliberate practice is sufficient to achieve elite status.

Hambrick disagrees.

"The evidence is quite clear," he writes, "that some people do reach an elite level of performance without copious practice, while other people fail to do so despite copious practice."

Hambrick and colleagues analyzed 14 studies of chess players and musicians, looking specifically at how practice was related to differences in performance. Practice, they found, accounted for only about one-third of the differences in skill in both music and chess.

So what made up the rest of the difference?

Based on existing research, Hambrick said it could be explained by factors such as intelligence or innate ability, and the age at which people start the particular activity. A previous study of Hambrick's suggested that working memory capacity ? which is closely related to general intelligence ? may sometimes be the deciding factor between being good and great.

While the conclusion that practice may not make perfect runs counter to the popular view that just about anyone can achieve greatness if they work hard enough, Hambrick said there is a "silver lining" to the research.

"If people are given an accurate assessment of their abilities and the likelihood of achieving certain goals given those abilities," he said, "they may gravitate toward domains in which they have a realistic chance of becoming an expert through deliberate practice."

###

Michigan State University: http://www.newsroom.msu.edu

Thanks to Michigan State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128329/Practice_makes_perfect__Not_so_much

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The Xbox One's Secret Killer Feature: Getting You in Shape

Yes, the new Xbox One is highly covetable for many reasons. But once you get past the games and the TV integration and the rumbling controllers, you finally land on what might be its most useful purpose: The world's most sophisticated workout gadget.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/EbZABkNqeyw/the-xbox-ones-secret-killer-feature-getting-you-in-sh-509243228

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Are the Kardashians Going Broke?

Source: http://www.thehollywoodgossip.com/2013/05/are-the-kardashians-going-broke/

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Timing of cancer radiation therapy may minimize hair loss

May 20, 2013 ? Discovering that mouse hair has a circadian clock -- a 24-hour cycle of growth followed by restorative repair -- researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

The study, which appears in the early online edition of the Proceedings of the National Academy of Sciences (PNAS), found that mice lost 85 percent of their hair if they received radiation therapy in the morning, compared to a 17 percent loss when treatment occurred in the evening.

The researchers, from the Salk Institute for Biological Studies, the University of Southern California (USC) and the University of California, Irvine (UCI), worked out the precise timing of the hair circadian clock, and also uncovered the biology behind the clockwork -- the molecules that tells hair when to grow and when to repair damage. They then tested the clock using radiotherapy.

"These findings are particularly exciting because they present a significant step towards developing new radiation therapy protocols that include minimizing negative side effects on normal tissues, such as hair or bone marrow, while maintaining the desired effects on cancer cells," says Maksim Plikus, assistant professor of developmental and cell biology at UCI and the study's first author. "We will now apply our findings to design novel circadian rhythm-based approaches to cancer therapy."

The scientists can't say their findings will directly translate to human cancer therapy because they haven't yet studied that possibility. But they say it is becoming increasingly clear that body organs and tissues have their own circadian clocks that, when understood, could be used to time drug therapy for maximum benefit.

"There are clocks everywhere in the body -- clocks that have their own unique rhythm that, we found, have little to do with the central clock in our brains," says the study's co-lead investigator, Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory and an expert on circadian rhythm.

"This suggests that delivering a drug to an organ while it is largely inactive is not a good idea. You could do more damage to the organ than when it is awake, repairing and restoring itself," says Panda. "If you know when an organ is mending itself, you might be able to deliver more potent doses of a drug or therapy. That might offer a better outcome while minimizing side effects."

Panda uses genetic, genomics and biochemical approaches to identify genes under circadian regulation in different organs and to understand the mechanism of such regulation. Plikus at UCI and Cheng-Ming Chuong, professor of pathology at the Keck School of Medicine of USC and the study's co-lead investigator, are experts on hair regeneration.

These researchers and their colleagues teamed together to find and then take apart the mouse hair circadian clock. It was a long and difficult study, Chuong says.

"Hair is a very complicated organ, featuring different types of cells going through different stages in the life cycle in a very tiny space," Chuong says. "We found that hair in mice grows fast in the morning and slows down at night, engaging a very powerful clock."

Every time hair cells divide, they pick up DNA damage that needs to be repaired. The scientists discovered that mice hair cells repair that damage primarily in the evening. This process is akin to using a kitchen dishwasher, Panda says.

"Most of us run the dishwasher after we have accumulated a lot of dirty dishes -- we don't run it every time a dish is dirty. The same is true for cells. They clean up -- repair their DNA -- at one time each day," Panda says.

Radiotherapy damages DNA in cells that divide rapidly, which is why it is used against growing cancer cells. That means that DNA damage to hair cells from radiotherapy delivered in the morning is not repaired until the evening, leading to hair loss. Damage from radiotherapy at night, however, is minimized because hair cells, already in the process of repairing DNA, can quickly heal.

"While we don't yet know if human hair follows that same clock we found in mice hair, it is true that facial hair in men grows during the day, resulting in the proverbial 5 o'clock shadow. There is no 5 a.m. shadow if you shave at night," Panda says.

The researchers found that cancer cells do not have circadian clocks, because they are dividing all the time.

"That means cancer therapy does not have to be timed to be more effective," Panda adds. "The timing has to do with minimizing collateral damage from normal cells affected by these treatments."

Scientists know for certain that other organs, such as the liver, use a circadian clock, and they suspect that all human tissue is similarly regulated, although the clocks may be timed differently.

"There are many clinical implications for this cacophony of internal clocks, beyond the timing of drug therapy," Panda says. "For example, some researchers suspect that obesity and diabetes occurs when an organ or organs -- perhaps the liver or stomach or pancreas -- should be sleeping, but is awoken by food that needs to be processed.

"These local clocks do a lot more things than the central clock in the brain, which primarily regulates sleeping," he says. "This field of research is exciting and may, someday, contribute to human health."

Other contributing authors are Christopher Vollmers and Amandine Chaix from Salk, Damon de la Cruz from USC, and Raul Ramos from UCI.

The study was supported by grants from the National Institutes of Health (AR 42177, AR47364, DK091618, P30 CA014195), The Leona M. and Harry B. Helmsley Charitable Trust, the Dana Foundation, the Glenn Foundation for Medical Research and the Edward Mallinckrodt Jr. Foundation. The authors declare no conflicts of interest.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/BUO49hE0GvY/130520163607.htm

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মঙ্গলবার, ২১ মে, ২০১৩

Desiree Hartsock, ABC's 'Bachelorette,' Discusses Gay 'Bachelor' Possibility (VIDEO)

Desiree Hartsock, ABC's latest "Bachelorette," dropped by HuffPost Live to discuss life on reality TV.

A HuffPost Live viewer grilled Hartsock why there wasn't a gay or lesbian "Bachelor" or "Bachelorette" yet. Check out the clip above to see what Hartsock had to say.

Of course, ten years ago Bravo had their own form of a gay "Bachelor" series, with America's first gay reality competition show, "Boy Meets Boy." The show, which had various men in a Palm Springs palace fighting for Bachelor James's heart, though some were secretly straight.

"Boy Meets Boy" was not renewed after the first season due to poor ratings and backlash from the gay community concerning the manipulative series.

Season 9 of "The Bachelorette" begins this upcoming Monday, May 27.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2013/05/21/desiree-hartsock-gay-bachelor_n_3313006.html

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Early-life traffic-related air pollution exposure linked to hyperactivity

May 21, 2013 ? Early-life exposure to traffic-related air pollution was significantly associated with higher hyperactivity scores at age 7, according to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center.

The research is detailed in a study being published Tuesday, May 21, in Environmental Health Perspectives, a peer-reviewed open access journal published by the National Institute of Environmental Health Sciences (NIEHS), an institute within the National Institutes of Health (NIH).

The research was conducted by faculty members from the UC College of Medicine's Department of Environmental Health in collaboration with Cincinnati Children's. Nicholas Newman, DO, director of the Pediatric Environmental Health and Lead Clinic at Cincinnati Children's, was the study's first author.

"There is increasing concern about the potential effects of traffic-related air pollution on the developing brain," Newman says. "This impact is not fully understood due to limited epidemiological studies.

"To our knowledge, this is the largest prospective cohort with the longest follow-up investigating early life exposure to traffic-related air pollution and neurobehavioral outcomes at school age." Scientists believe that early life exposures to a variety of toxic substances are important in the development of problems later in life.

Newman and his colleagues collected data on traffic-related air pollution (TRAP) from the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a long-term epidemiological study examining the effects of traffic particulates on childhood respiratory health and allergy development. Funded by the National Institute of Environmental Health Sciences, CCAAPS is led by Grace LeMasters, PhD, of the environmental health department. Study participants -- newborns in the Cincinnati metropolitan area from 2001 through 2003 -- were chosen based on family history and their residence being either near or far from a major highway or bus route.

Children were followed from infancy to age 7, when parents completed the Behavioral Assessment System for Children, 2nd Edition (BASC-2), assessing attention deficit hyperactivity disorder (ADHD) and related symptoms including attention problems, aggression, conduct problems and atypical behavior. Of the 762 children initially enrolled in the study, 576 were included in the final analysis at 7 years of age.

Results showed that children who were exposed to the highest third amount of TRAP during the first year of life were more likely to have hyperactivity scores in the "at risk" range when they were 7 years old. The "at risk" range for hyperactivity in children means that they need to be monitored carefully because they are at risk for developing clinically important symptoms.

"Several biological mechanisms could explain the association between hyperactive behaviors and traffic-related air pollution," Newman says, including narrowed blood vessels in the body and toxicity in the brain's frontal cortex.

Newman notes that the higher air pollution exposure was associated with a significant increase in hyperactivity only among those children whose mothers had greater than a high school education. Mothers with higher education may expect higher achievement, he says, affecting the parental report of behavioral concerns.

"The observed association between traffic-related air pollution and hyperactivity may have far-reaching implications for public health," Newman says, noting that studies have shown that approximately 11 percent of the U.S. population lives within 100 meters of a four-lane highway and that 40 percent of children attend school within 400 meters of a major highway.

"Traffic-related air pollution is one of many factors associated with changes in neurodevelopment, but it is one that is potentially preventable."

LeMasters, Patrick Ryan, PhD, Linda Levin, PhD, David Bernstein, MD, Gurjit Khurana Hershey, MD, PhD, James Lockey, PhD, Manuel Villareal, MD, Tiina Reponen, PhD, Sergey Grinshpun, PhD, Heidi Sucharew, PhD, and Kim Dietrich, PhD, were co-authors of the study.

Funding was provided by NIEHS and the National Institute for Occupational Safety and Health (NIOSH).

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/puxdw3mCYNE/130521011234.htm

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Extreme solar storm threatens Earth's electrical grids

WASHINGTON ? If an extreme solar storm aimed at the Earth hits in just the right way, it could put interconnected electrical grids around the world at serious risk, experts say.

In addition to creating beautiful auroras, extreme solar storms could knock out a wide range of electric utilities needed to keep life in the United States and around the world functioning normally, according to presenters here at the fourth annual Electrical Infrastructure Security Summit.

"What [a solar storm] can do ? even if it isn't causing a continental-scale outage ? it can really cause a regional blackout," said Daniel Baker, director of the Laboratory for Atmospheric and Space Physics at the University of Colorado. "Imagine something like, for example, Superstorm Sandy. Imagine that kind of severe storm ? but causing regional outages for weeks. Living without power really cascades and propagates in remarkable ways throughout our society." [The Worst Solar Storms in History]

As the sun reaches the peak in its 11-year cycle this year, scientists expect that active regions of the star ? known as sunspots ? will erupt, flinging streams of charged particles out into the solar system. Relatively minor storms can also create temporary radio blackouts and disrupt GPS navigation.

However, this doesn't necessarily mean that all solar eruptions will impact the Earth. Most coronal mass ejections are not aimed toward the planet, and instead shoot out harmlessly into other parts of the solar system. But once every century or so, an extreme solar storm is expected to impact the Earth, Baker told SPACE.com. ?

The last documented solar storm in this category is known as the Carrington event. Particles from a powerful coronal mass ejection overloaded telegraph wires, setting paper messages on fire in 1859.

These kinds of storms from the sun are notoriously difficult to predict. Experts understand the general conditions under which solar storms occur, but it's hard to forecast just how powerful the storm will be, said Karel Schrijver, a solar scientist and fellow at Lockheed Martin.

"A [coronal mass ejection] takes two to four days to get to the Earth, so if we had more observational resources, to map its motion ? and if we had some measurements of the structure of what's going to hit you ? there are ways by which we can certainly improve the forecast," Schrijver told SPACE.com.

Scientists can use sun-observing satellites like NASA's Solar Dynamics Observatory to monitor, and possibly forecast, solar weather that could be heading toward the planet, Schrijver said.

"There's a lot of space to be explored in terms of computer models that are becoming ever more powerful," Schrijver added. "The heliophysics division at NASA has a wonderful fleet of observatories that looks at the space between the sun and the Earth and the Earth's environment."

Follow Miriam Kramer?@mirikramer?and?Google+. Follow us?@Spacedotcom,?Facebook?and?Google+. Original article on?SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/extreme-solar-storm-could-cause-widespread-disruptions-earth-133434128.html

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What 'Star Wars: Episode VII' Needs: Malakili

By Ryan Rigley Seems like we here at MTV News aren't the only ones speculating about what to expect from the upcoming "Star Wars" trilogy. Last Wednesday, on Jimmy Kimmel Live, "Star Wars" fans were given the opportunity to give the "Star Trek Into Darkness" director (J. J. Abrams) a few suggestions of their own. [...]

Source: http://moviesblog.mtv.com/2013/05/20/star-wars-episode-vii-malakili/

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Timing of cancer radiation therapy may minimize hair loss

May 20, 2013 ? Discovering that mouse hair has a circadian clock -- a 24-hour cycle of growth followed by restorative repair -- researchers suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.

The study, which appears in the early online edition of the Proceedings of the National Academy of Sciences (PNAS), found that mice lost 85 percent of their hair if they received radiation therapy in the morning, compared to a 17 percent loss when treatment occurred in the evening.

The researchers, from the Salk Institute for Biological Studies, the University of Southern California (USC) and the University of California, Irvine (UCI), worked out the precise timing of the hair circadian clock, and also uncovered the biology behind the clockwork -- the molecules that tells hair when to grow and when to repair damage. They then tested the clock using radiotherapy.

"These findings are particularly exciting because they present a significant step towards developing new radiation therapy protocols that include minimizing negative side effects on normal tissues, such as hair or bone marrow, while maintaining the desired effects on cancer cells," says Maksim Plikus, assistant professor of developmental and cell biology at UCI and the study's first author. "We will now apply our findings to design novel circadian rhythm-based approaches to cancer therapy."

The scientists can't say their findings will directly translate to human cancer therapy because they haven't yet studied that possibility. But they say it is becoming increasingly clear that body organs and tissues have their own circadian clocks that, when understood, could be used to time drug therapy for maximum benefit.

"There are clocks everywhere in the body -- clocks that have their own unique rhythm that, we found, have little to do with the central clock in our brains," says the study's co-lead investigator, Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory and an expert on circadian rhythm.

"This suggests that delivering a drug to an organ while it is largely inactive is not a good idea. You could do more damage to the organ than when it is awake, repairing and restoring itself," says Panda. "If you know when an organ is mending itself, you might be able to deliver more potent doses of a drug or therapy. That might offer a better outcome while minimizing side effects."

Panda uses genetic, genomics and biochemical approaches to identify genes under circadian regulation in different organs and to understand the mechanism of such regulation. Plikus at UCI and Cheng-Ming Chuong, professor of pathology at the Keck School of Medicine of USC and the study's co-lead investigator, are experts on hair regeneration.

These researchers and their colleagues teamed together to find and then take apart the mouse hair circadian clock. It was a long and difficult study, Chuong says.

"Hair is a very complicated organ, featuring different types of cells going through different stages in the life cycle in a very tiny space," Chuong says. "We found that hair in mice grows fast in the morning and slows down at night, engaging a very powerful clock."

Every time hair cells divide, they pick up DNA damage that needs to be repaired. The scientists discovered that mice hair cells repair that damage primarily in the evening. This process is akin to using a kitchen dishwasher, Panda says.

"Most of us run the dishwasher after we have accumulated a lot of dirty dishes -- we don't run it every time a dish is dirty. The same is true for cells. They clean up -- repair their DNA -- at one time each day," Panda says.

Radiotherapy damages DNA in cells that divide rapidly, which is why it is used against growing cancer cells. That means that DNA damage to hair cells from radiotherapy delivered in the morning is not repaired until the evening, leading to hair loss. Damage from radiotherapy at night, however, is minimized because hair cells, already in the process of repairing DNA, can quickly heal.

"While we don't yet know if human hair follows that same clock we found in mice hair, it is true that facial hair in men grows during the day, resulting in the proverbial 5 o'clock shadow. There is no 5 a.m. shadow if you shave at night," Panda says.

The researchers found that cancer cells do not have circadian clocks, because they are dividing all the time.

"That means cancer therapy does not have to be timed to be more effective," Panda adds. "The timing has to do with minimizing collateral damage from normal cells affected by these treatments."

Scientists know for certain that other organs, such as the liver, use a circadian clock, and they suspect that all human tissue is similarly regulated, although the clocks may be timed differently.

"There are many clinical implications for this cacophony of internal clocks, beyond the timing of drug therapy," Panda says. "For example, some researchers suspect that obesity and diabetes occurs when an organ or organs -- perhaps the liver or stomach or pancreas -- should be sleeping, but is awoken by food that needs to be processed.

"These local clocks do a lot more things than the central clock in the brain, which primarily regulates sleeping," he says. "This field of research is exciting and may, someday, contribute to human health."

Other contributing authors are Christopher Vollmers and Amandine Chaix from Salk, Damon de la Cruz from USC, and Raul Ramos from UCI.

The study was supported by grants from the National Institutes of Health (AR 42177, AR47364, DK091618, P30 CA014195), The Leona M. and Harry B. Helmsley Charitable Trust, the Dana Foundation, the Glenn Foundation for Medical Research and the Edward Mallinckrodt Jr. Foundation. The authors declare no conflicts of interest.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/BUO49hE0GvY/130520163607.htm

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